Kadar Homosistein dan Risiko Kardiovaskular

Oleh :

dr.I.B. Komang Arjawa, Sp.JP, FIHA

Peningkatan kadar homosistein telah dikaitkan dengan penyakit kardiovaskular seperti aterosklerosis dan penyakit jantung koroner. Meski demikian, masih terdapat kontroversi mengenai signifikansi homosistein sebagai faktor risiko penyakit kardiovaskular dan apakah skrining homosistein perlu dilakukan secara rutin.[1-4]

Metabolisme Homosistein dan Efek Hiperhomosisteinemia

Homosistein merupakan bagian nonproteinogenik asam amino yang diproduksi sebagai produk intermediata dari metabolisme metionin. Homosistein selanjutnya dapat dimetabolisme menjadi cystathionine melalui jalur cystathionine beta synthetase yang merupakan enzim bergantung vitamin B6. Selain itu, homosistein juga dapat melalui proses remetilasi ulang menjadi metionin dengan jalur betaine Hcy methyl-transferase atau jalur methionine synthase.[4,5]

(Konten ini khusus untuk dokter. Registrasi untuk baca selengkapnya)

Referensi

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