Penatalaksanaan Limfoma Hodgkin

Oleh :

dr. Nurul Falah

Penatalaksanaan limfoma Hodgkin adalah radioterapi atau kemoterapi regimen ABVD, yang terdiri dari doxorubicin/bleomycin/vinblastine/dacarbazine, maupun BEACOPP. Durasi terapi berbeda berdasarkan staging Ann Arbor dengan revisi Cotswold dan faktor prognostik. Kemoterapi dapat dikombinasi dengan radioterapi sesuai staging.[3,36]

European Organization for Research and Treatment of Cancer (EORTC) mengelompokkan pasien dalam terapi untuk limfoma hodgkin klasik ke dalam 3 stage berdasarkan kriteria stadium LH dengan ada atau tidak adanya faktor risiko, yakni:

Limited stages, yaitu stadium I–II tanpa faktor risiko

Intermediate stages, yaitu stadium I–2 dengan ≥1 faktor risiko

Advanced-stage disease, yaitu stadium III–V dengan/tanpa faktor risiko[2,20,21,36]

Referensi

2. Lash BD. Hodgkin Lymphoma. Emedicine.medscape.com. 2018. https://emedicine.medscape.com/article/201886-overview#showall
3. Kaseb H, Babiker HM. Hodgkin Lymphoma. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK499969/
20. Hoppe RT, Advani RH, Ai WZ, Ambinder RF, Aoun P, et al. NCCN Guidelines Insights: Hodgkin Lymphoma, Version 1.2018. J Natl Compr Canc Netw. 2018;16(3):245-254.
21. Fermé C, Thomas J, Brice P, Casasnovas O, Vranovsky A, et al. ABVD or BEACOPP baseline along with involved-field radiotherapy in early-stage Hodgkin Lymphoma with risk factors: Results of the European Organisation for Research and Treatment of Cancer (EORTC)-Groupe d'Étude des Lymphomes de l'Adulte (GELA) H9-U intergroup randomised trial. Eur J Cancer. 2017;81:45-55.
22. Annibali O, Pensieri C, Tomarchio V, et al. Protective Isolation for Patients with Haematological Malignancies: A Pilot Study Investigating Patients’ Distress and Use of Time. Int J Hematol Oncol Stem Cell Res. 2017;11(4):313-8.
23. Klimm B, Goergen H, Fuchs M, von Tresckow B, Böll B, et al. Impact of risk factors on outcomes in early-stage Hodgkin's lymphoma: an analysis of international staging definitions. Ann. Oncol. 2013;24(12):3070-6.
24. Fitzgerald TJ. Optimisation of adaptive therapy for advanced Hodgkin lymphoma. The Lancet Oncology. 2019. doi:10.1016/s1470-2045(19)30005-1.
25. Connors JM. Advanced-stage Hodgkin lymphoma: New approaches based on novel therapeutic agents of treatment intensification. Cancer J. 2018;24(5):230-6.
26. Specht L. Radiotherapy for Hodgkin lymphoma: Reducing toxicity while maintaining efficacy. Cancer J. 2018; 24(5):237-43.
27. Connors JM. I. Hodgkin Lymphoma: Special Challenges and Solutions. Hematological Oncology. 2015;33:21-4.
36. Eichenauer DA, Aleman BMP, Andre M, Federico M, Hutchings M, et al. Hodgkin lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology 29 (Supplement 4): iv19–iv29, 2018. doi:10.1093/annonc/mdy080
37. PDQ Pediatric Treatment Editorial Board. Childhood Hodgkin Lymphoma Treatment (PDQ®): Health Professional Version. 2023 Mar 24. In: PDQ Cancer Information Summaries . Bethesda (MD): National Cancer Institute (US), Table 4. Ann Arbor Staging Classification for Hodgkin Lymphoma. https://www.ncbi.nlm.nih.gov/books/NBK65726/table/CDR0000062933__557/
38. Moccia AA, Donaldson J, Chhanabhai M, Hoskins PJ, Klasa RJ, et al. International Prognostic Score in Advanced-Stage Hodgkin's Lymphoma: Altered Utility in the Modern Era. Journal of Clinical Oncology, 2012 30:27, 3383-3388

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Penatalaksanaan Limfoma Hodgkin

Referensi

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