Efek Samping dan Interaksi Obat Ringer Laktat

Oleh :

Josephine Darmawan

Efek samping ringer laktat atau RL cukup jarang terjadi. RL adalah cairan kristaloid dengan osmolaritas 273 mOsm/L dan pH sekitar 6,5, sehingga risiko efek samping di antaranya asidosis laktat dan hiperkalemia. Interaksi obat dapat terjadi karena RL bersifat alkali/basa dan mengandung kalium dan kalsium, sehingga akan mempengaruhi eliminasi obat-obatan di organ ginjal.[3-5]

Efek Samping

Risiko efek samping pemberian RL antara lain:

Referensi

1. Keputusan Menteri Kesehatan Republik Indonesia No. HK.01.07/MENKES/688/2019 Tentang Daftar Obat Esensial Nasional. 2019. Kemenkes.
2. National Centre for Biotechnology Information. Hartmann’s Solution. PubChem Compound Database. 2022. https://pubchem.ncbi.nlm.nih.gov/compound/6335487
3. Singh S, Kerndt CC, Davis D. Ringer's Lactate. Treasure Island (FL): StatPearls Publishing; 2022 Jan. https://www.ncbi.nlm.nih.gov/books/NBK500033/
4. Drug.com. Lactated Ringers. 2022. https://www.drugs.com/pro/lactated-ringers
5. Mane A. Fluid Resuscitation : Ringer Lactate Versus Normal Saline-A clinical Study. Int J Contemp Med Res. 2017;4:2290–3.
6. Pusat Informasi Obat Nasional. Natrium Laktat + Kalium Klorida + Kalsium Klorida. BPOM RI. 2022.
7. MIMS Indonesia. Lactated Ringers solution. Mims.com. 2022. https://www.mims.com/indonesia/drug/info
8. Therapeutic Goods Administration. Prescribing medicines in pregnancy database. TGA. 2022. https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname
9. Medscape. Sodium Lactate (Rx). 2022. https://reference.medscape.com/drug/sodium-lactate-342856#0
10. New Zealand Medicines and Medical Devices Safety Authority. Compound Sodium Lactate (Hartmann’s) Solution for Injection Product Information. Medsafe. 2022. http://www.medsafe.govt.nz/profs/
11. Procter, LD. Intravenous Fluid Resuscitation. MSD Manual Professional Version. MSD: 2019. https://www.msdmanuals.com/professional/critical-care-medicine/shock-and-fluid-resuscitation/intravenous-fluid-resuscitation#
12. Mehta M, Tudor GJ. Parkland Formula.StatPearls Publishing; 2022 Jan. https://www.ncbi.nlm.nih.gov/books/NBK537190/
13. Habib ME, Saadah LM, Al-Samerrae M, Shoeib FE, Mamoun M, Latif GA, et al. Does Ringer Lactate Used in Parkland Formula for Burn Resuscitation Adequately Restore Body Electrolytes and Proteins? Mod Plast Surg. 2017;07:1–12.
14. Smith DS. Dengue Treatment & Management. 2019. Medscape. https://emedicine.medscape.com/article/215840-treatment#d9
15. McDougall M, Guthrie B, Doyle A, et alIntroducing NICE guidelines for intravenous fluid therapy into a district general hospitalBMJ Open Quality 2022;11:e001636. doi: 10.1136/bmjoq-2021-001636
16. Anigilaje EA. Management of Diarrhoeal Dehydration in Childhood: A Review for Clinicians in Developing Countries. Frontiers in Pediatr. 2018;6(28):1-19.
17. Edelson JB, Orenstein EW, Zaotis LB, Copelovitch L. Intravenous fluid management in the pediatric hospital setting: Is isotonic fluid the right approach for all patients? Hospital medicine. 2015;1:90-9.
18. Petik D, Puhó E, Czeizel AE. Evaluation of maternal infusion therapy during pregnancy for fetal development. Int J Med Sci. 2005;2:137–42.National Institute for Clinical Excellence. Intravenous fluid therapy in adults in hospital. NICE Clin Guidel. 2013;1–37

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