Patofisiologi Disseminated Intravascular Coagulation (DIC)

Oleh :

dr. Queen Sugih Ariyani

Patofisiologi disseminated intravascular coagulation (DIC) dipengaruhi oleh paparan tissue factor jumlah besar yang menyebabkan kompensasi hemostasis tidak dapat mengatasi status hiperkoagulasi. DIC juga dipengaruhi paparan sitokin proinflamasi, terutama tumor necrosis factor (TNF), interleukin (IL) 1, dan IL-6, yang akan menyebabkan gangguan keseimbangan sistem koagulasi.

Paparan Tissue Factor pada Thrombin

Aktivasi dan inisiasi koagulasi yang menyebabkan terbentuknya thrombin pada DIC, diperantarai oleh tissue factor/factor VIIa pathway. Paparan tissue factor (TF) pada sirkulasi terjadi melalui kerusakan endotel dan jaringan, serta inflamasi. TF akan memicu molekul prokoagulan dan mengaktivasi jalur koagulasi yang melibatkan faktor VIIa. Kompleks TF-VIIa akan mengaktivasi thrombin yang mengubah fibrinogen menjadi fibrin. Di saat yang bersamaan thrombin juga mengaktifkan agregasi platelet.

Referensi

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