Diagnosis Severe Acute Respiratory Syndrome (SARS)

Oleh :

dr. Nurul Falah

Baku emas diagnosis severe acute respiratory syndrome (SARS) adalah pemeriksaan laboratorium reverse–transcriptase polymerase chain reaction (RT–PCR). Apabila RT–PCR tidak tersedia atau sulit dilakukan, penegakkan diagnosis dapat dilakukan melalui anamnesis riwayat kontak dengan orang berisiko, musang bulan dan kelelawar. Pemeriksaan fisik akan menunjukkan gejala respirasi seperti batuk sampai sesak napas, serta gejala infeksi sistemik berat, dari sepsis hingga syok.[1–5]

Definisi Kasus SARS

Untuk memberikan gambaran epidemiologi SARS dan memantau penyebarannya, maka definisi dari kasus SARS perlu ditetapkan. Menurut WHO, definisi kasus SARS terbagi menjadi 2 yaitu kasus suspect dan probable.

Referensi

1. Chan-Yeung M, Xu RH. SARS: epidemiology. Respirology. 2003;8(1):S9‐S14.
2. WHO. Consensus document on the epidemiology of severe acute respiratory syndrome (SARS). WHO, 2003. https://www.who.int/csr/sars/en/WHOconsensus.pdf
3. Chen J, Subbarao K. The Immunobiology of SARS*. Annu Rev Immunol. 2007;25:443‐472.
4. Ksiazek TG, Erdman D, Goldsmith C, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003; 348.
5. Wang LF, Eaton BT. Bats, civets and the emergence of SARS. Curr Top Microbiol Immunol. 2007;315:325‐344.
11. Poutanen SM, Low DE, Henry B, et al. Identification of severe acute respiratory syndrome in Canada. N Engl J Med. 2003:348.
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18. Peiris JS, Lai ST, Poon LL, et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361:1319-25.
19. Goldsmith CS, Tatti KM, Ksiazek TG, et al. Ultrastructural characterization of SARS coronavirus. Emerg Infect Dis. 2004;10(2):320‐326.
20. Freeman AM, Leigh, Jr TR. Viral Pneumonia. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK513286/
21. Sattar SBA, Sharma S. Bacterial Pneumonia. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK513321/
22. Booth TF, Kournikakis B, Bastien N, et al. Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units. J Infect Dis. 2005;191(9):1472‐1477.
23. Chui L, Drebot M, Andonov A, et al. Comparison of 9 different PCR primers for the rapid detection of severe acute respiratory syndrome coronavirus using 2 RNA extraction methods. Diagn Microbiol Infect Dis. 2005;53(1):47‐55.
24. WHO. Summary of the Discussions and Recommendations of the SARS Laboratory Workshop; 22 October 2003; 2003. http://www.who.int/csr/sars/guidelines/en/SARSLabmeeting.pdf
25. Yam WC, Chan KH, Poon LL, et al. Evaluation of reverse transcription-PCR assays for rapid diagnosis of severe acute respiratory syndrome associated with a novel coronavirus. J Clin Microbiol. 2003;41(10):4521‐4524.
26. Ng LF, Wong M, Koh S, et al. Detection of severe acute syndrome coronavirus in blood of infected patients. J Clin Microbiol. 2004;42(1):347-50.
27. Chen X, Zhou B, Li M, et al. Serology of severe acute respiratory syndrome: Implications for surveillance and outcome. J Infect Dis. 2004;189(7):1158-63.
28. Lee N, Hui D, Wu A, et al. A major outbreak of severe acute respiratory syndrome in Hongkong. N Engl J Med. 2003;348(20):1986-94.
29. Centers for Disease Control and Prevention. 2003. Severe Acute Respiratory Syndrome. http://www.cdc.gov/ncidod/sars/
30. Wong KT, Antonio GE, Hui DS, et al. Severe acute respiratory syndrome: radiographic appearances and pattern of progression in 138 patients. Radiology. 2003; 228:401–406.
31. Paul NS, Roberts H, Butany J, et al. Radiologic pattern of disease in patients with severe acute respiratory syndrome: the Toronto experience. RadioGraphics. 2004; 24:553–563.
32. 32. Centers for Disease Control and Prevention. Clinical Guidance on the Identification and Evaluation of Possible SARS-CoV Disease among Persons Presenting with Community-Acquired Illness, Version 2. Centers for Disease Control and Prevention. http://www.cdc.gov/ncidod/sars/clinicalguidance.htm.
51. Hodgens A, Gupta V. Severe Acute Respiratory Syndrome. In: StatPearls Treasure Island (FL): StatPearls Publishing; 2022 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK558977/

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