Indikasi dan Dosis Methylprednisolone

Oleh :

dr.Eveline Yuniarti

Indikasi methylprednisolone adalah sebagai antiinflamasi atau imunosupresan dalam berbagai kondisi medis, seperti sindrom Stevens-Johnson, multiple sclerosis, reaksi penolakan pada transplantasi organ, dan kondisi alergi. Dosis memerlukan tapering dan penggunaan jangka lama atau dosis tinggi tidak boleh dihentikan secara mendadak.[2,3,18]

Indikasi

Methylprednisolone memiliki efek antiinflamasi dan imunosupresan yang bermanfaat dalam berbagai kondisi medis berikut:

Referensi

1. Mehta J, Rolta R, Mehta BB, Kaushik N, Choi EH, Kaushik NK. Role of Dexamethasone and Methylprednisolone Corticosteroids in Coronavirus Disease 2019 Hospitalized Patients: A Review. Vol. 13, Frontiers in Microbiology. Frontiers Media S.A.; 2022.
2. MIMS. Methylprednisolone. 2026. https://www.mims.com/indonesia/drug/info/methylprednisolone?mtype=generic
3. Drugbank. Methylprednisolone. 2026. https://go.drugbank.com/drugs/DB00959
4. Xiang Z, Liu J, Shi D, Chen W, Li J, Yan R, et al. Glucocorticoids improve severe or critical covid-19 by activating ace2 and reducing il-6 levels. International Journal of Biological Sciences. 2020;16(13):2382–91.
11. Dogan N, Hüsing-Kabar A, Schmidt HH, Cicinnati VR, Beckebaum S, Kabar I. Acute allograft rejection in liver transplant recipients: Incidence, risk factors, treatment success, and impact on graft failure. Journal of International Medical Research. 2018 Sep 1;46(9):3979–90.
13. Ikatan Dokter Anak Indonesia. Formularium Spesialistik Ilmu Kesehatan Anak. 2013.
16. Ye ZW, Yuan S, Chan JFW, Zhang AJ, Yu CY, Ong CP, et al. Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection. Emerging Microbes and Infections. 2021;10(1):291–304.
17. Hong S, Wang H, Zhang Z, Qiao L. The roles of methylprednisolone treatment in patients with COVID-19: A systematic review and meta-analysis. Vol. 183, Steroids. Elsevier Inc.; 2022.
18. ASHP. Methylprednisolone. 2026. https://www.drugs.com/monograph/methylprednisolone.html
19. Lai X, Liu L, Zhang Z, Shi L, Yang G, Wu M, et al. Hepatic veno-occlusive disease/sinusoidal obstruction syndrome after hematopoietic stem cell transplantation for thalassemia major: incidence, management, and outcome. Bone Marrow Transplantation. 2021 Jul 1;56(7):1635–41.
20. Jonczyk M, Schol IM, Tratnig-Frankl P, Lellouch AG, Ko DSC, Cetrulo CL. 3281 Management of Acute Rejection in Penile Allotransplantation. Journal of Clinical and Translational Science. 2019 Mar;3(s1):15–6.
21. Chan OW, Lin JJ, Hsia SH, Lin CY, Lin KL. Methylprednisolone pulse therapy as an adjuvant treatment of Streptococcus pneumoniae meningitis complicated by cerebral infarction—a case report and review of the literature. Child’s Nervous System. 2020 Feb 1;36(2):229–33.
22. Palaskas N, Lopez-Mattei J, Durand JB, Iliescu C, Deswal A. Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment. J Am Heart Assoc. 2020 Jan 21;9(2).
23. Floyd L, Morris AD, Shetty A, Brady ME, Ponnusamy A, Warwicker P, Dhaygude A. Low-Dose Intravenous Methylprednisolone in Remission Induction Therapy for ANCA-Associated Vasculitis. Kidney360. 2023 Sep 1;4(9):e1286-e1292. doi: 10.34067/KID.0000000000000222.
27. Lewandowski KC, Kawalec J, Kusiński M, Dąbrowska K, Matusiak AE, Dudek I, Lewiński A. The Utility of Intravenous Methylprednisolone as an Adjunct Treatment for Drug-Resistant Amiodarone-Induced Thyrotoxicosis. J Clin Med. 2024 Jan 6;13(2):324. doi: 10.3390/jcm13020324.
37. FDA. Methylprednisolone. 2018. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/011153s075lbl.pdf

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