Indikasi dan Dosis Carvedilol

Oleh :

Josephine Darmawan

Indikasi dan dosis pemberian carvedilol / karvedilol berbeda-beda tergantung kondisi yang menyertai. Secara umum, dosis awal carvedilol adalah 3.125 mg 2 kali sehari dengan dosis maksimal 25-50 mg, dua kali sehari. [2,5,14]

Gagal Jantung

Carvedilol merupakan beta blocker pilihan pada gagal jantung dengan penurunan fraksi ejeksi. Perlu diperhatikan bahwa carvedilol tidak dapat digunakan sebagai terapi tunggal dan harus digunakan bersamaan dengan obat lain.

Referensi

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Furman B. Carvedilol. Ref Modul Biomed Sci. 2018;1–4.
5. MIMS Indonesia. Carvedilol. MIMS Indonesia. 2018. https://www.mims.com/indonesia/drug/info/carvedilol/
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7. Schwarzer R, Kivaranovic D, Paternostro R, Mandorfer M, Reiberger T, Trauner M, et al. Carvedilol for reducing portal pressure in primary prophylaxis of variceal bleeding: a dose-response study. Aliment Pharmacol Ther. 2018;47:1162–9.
8. Huang Y, Li T, Ke W, Xian W, Li J, Zheng Q, et al. Carvedilol for portal hypertension in cirrhosis: systematic review with meta-analysis. Vol. 6, BMJ Open. 2016. p. e010902.
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11. Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI). Panduan Praktik Klinis (PPK) dan Clinical Pathway (CP) Penyakit Jantung dan Pembuluh Darah. Ed 1. PERKI. 2016.
13. Drugs.com. Carvedilol. Drugs.com. 2024. https://www.drugs.com/pro/carvedilol.html
14. American College of Cardiology. Carvedilol. American College of Cardiology. 2019. https://www.acc.org/tools-and-practice-support/clinical-toolkit
15. Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI). Pedoman Tatalaksana Gagal Jantung. Ed 1. PERKI. 2015. h 14-28.
16. Okamoto H, Hori M, Matusuzaki M, Tsutsui H, Yamazaki T, Nagai R, et al. Minimal dose for effective clinical outcome and predictive factors for responsiveness to carvedilol: Japanese chronic heart failure (J-CHF) study. Int J Cardiol. 2013;164:238–44.
17. Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI). Pedoman Tata Laksana Fibrilasi Atrium. 2014.
18. Whelton P, Carey R, Aronow W, Casey D, Himmelfarb C, DePalma S, et al. 2017 ACC / AHA / AAPA / ABC / ACPM / AGS / APhA /ASH / ASPC / NMA / PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. J Am Coll Cardiol. 2017;71:e127–248.
19. Tripathi D, Stanley AJ, Hayes PC, Patch D, Millson C, Mehrzad H, et al. UK guidelines on the management of variceal haemorrhage in cirrhotic patients. Gut. 2015;64:1680–704.

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