Prognosis Non-alcoholic Fatty Liver

Oleh :

dr.Monica

Prognosis dan risiko komplikasi non-alcoholic fatty liver (NAFL), atau perlemakan hati non-alkoholik, bervariasi tergantung pada tingkat keparahan penyakit dan apakah telah terjadi progresi ke tahap yang lebih lanjut seperti non-alcoholic steatohepatitis (NASH) atau sirosis hati. Pada tahap awal NAFL, prognosis umumnya baik. Namun, ketika NAFL berkembang menjadi NASH, terjadi peradangan dan kerusakan hati yang lebih serius, meningkatkan risiko perkembangan sirosis dan karsinoma hepatoseluler (HCC).[2,3,12]

Komplikasi

NAFL dapat berkembang menjadi berbagai komplikasi serius, terutama jika mencapai tahap yang lebih berat seperti non-alcoholic steatohepatitis (NASH) atau sirosis hati. Pada tahap sirosis, pasien dapat mengalami asites, varises esofagus, perdarahan varises esofagus, hipertensi portal, hingga gagal jantung.[1-3,19-22]

Referensi

1. European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), European Association for the Study of Obesity (EASO). EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease. Journal of Hepatology. 2016:64;1388-42.
2. Basu R, Noureddin M, Clark JM. Nonalcoholic fatty liver disease: review of management for primary care providers. Mayo Clin Proc 2022; 97:1700-16. https://doi.org/10.1016/j.mayocp.2022.04.005.
3. Eslam M, Sarin SK, Wong VWS, Fan JG, Kawaguchi T, Ahn SH, et al. The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease. Hepatol Int 2020; 14:889-919. https://doi.org/10.1007/s12072-020-10094-2.
12. Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, et al. The Diagnosis and Management of Nonalcoholic Fatty Liver Disease: Practice Guidance From the American Association for the Study of Liver Diseases. 2017. https://doi.org/10.1002/hep.29367/ suppinfo.
19. Petrelli F, Manara M, Colombo S, de Santi G, Ghidini M, Mariani M, et al. Hepatocellular carcinoma in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis: HCC and Steatosis or Steatohepatitis. Neoplasia (United States). 2022;30. https://doi.org/10.1016/j.neo.2022.100809.
20. Orci LA, Sanduzzi-Zamparelli M, Caballol B, Sapena V, Colucci N, Torres F, et al. Incidence of Hepatocellular Carcinoma in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review, Meta-analysis, and Meta-regression. Clinical Gastroenterology and Hepatology. 2022;20:283-292.e10. https://doi.org/10.1016/ j.cgh.2021.05.002.
21. Kariyama K, Kawanaka M, Nouso K, Hiraoka A, Toyoda H, Tada T, et al. Fibrosis-3 Index: A New Score to Predict Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Without Age as a Factor. Gastro Hep Advances 2022;1:1108-13. https://doi.org/ 10.1016/j.gastha.2022.07.012.
22. Wu J, Guo J, Wang A, Zhang Y, Wu S, Liu Y, et al. Nonalcoholic fatty liver disease and risk of intracerebral hemorrhage. Nutrition, Metabolism and Cardiovascular Diseases 2022;32:2561-7. https:// doi.org/10.1016/j.numecd.2022.08.010.

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