Etiologi Adolescent Idiopathic Scoliosis

Oleh :

dr.Nailla Fariq Alfiani

Etiologi adolescent idiopathic scoliosis (AIS), atau skoliosis idiopatik pada remaja, masih belum diketahui pasti, walaupun telah dilakukan penelitian selama bertahun-tahun. Berdasarkan teori, penyebab AIS mencakup kelainan biomekanik, hormonal, metabolik, neuromuskuler, genetik, dan lingkungan.[5,8-10]

Teori Biomekanik

Teori biomekanik menggambarkan bahwa human spine merupakan konstruksi yang bergerak-gerak dan tidak stabil, jika dibandingkan dengan spesies lainnya. Oleh karena itu, perkembangan tulang belakang manusia dapat mengalami deformitas rotasi yang progresif.[5-10]

Referensi

3. Charles Hoo and Luthfi Gatam. Role of Remodelling in Adolescent Idiopathic Scoliosis: an Evaluation of Osteopontin Level. 2012. https://media.neliti.com/media/publications/90446-EN-role-of-remodelling-in-adolescent-idiopa.pdf
5. Tom P.C., Schlösser, Dino Colo, and René M. Castelein. Etiology and pathogenesis of adolescent idiopathic scoliosis. 2015. https://sci-hub.se/https://doi.org/10.1053/j.semss.2015.01.003
6. GQ Sun, NG Bobby, and Annie Yim et all. High osteopontin plasma level associated with abnormal cortical bone mineral density in girls with adolescent idiopathic scoliosis. 2012. https://www.researchgate.net/publication/228088449_High_osteopontin_plasma_level_associated_with_abnormal_cortical_bone_mineral_density_in_girls_with_adolescent_idiopathic_scoliosis
7. Charles T Mehlman. Idiopathic Scoliosis. 2023. https://emedicine.medscape.com/article/1265794-overview#a9
8. Maja Fadzan and Josette Bettany-Saltikov. Etiological Theories of Adolescent Idiopathic Scoliosis: Past and Present. 2020. https://openorthopaedicsjournal.com/VOLUME/11/PAGE/1466/FULLTEXT/
9. Richard Geoffrey Burwell, Emma M. Clark, and Peter Dangerfield. Adolescent idiopathic scoliosis (AIS): A multifactorial cascade concept for pathogenesis and embryonic origin. 2016. https://www.researchgate.net/publication/292385536_Adolescent_idiopathic_scoliosis_AIS_A_multifactorial_cascade_concept_for_pathogenesis_and_embryonic_origin
10. Safak Ekinci and Omer Ersen. Adolescent Idiopathic Scoliosis. 2013. https://www.ejmaces.com/ejmaces-articles/adolescent-idiopathic-scoliosis.pdf
11. Emre Acaroglu, Regis Bobe, Jocelyn Enouf, Ralph Marcucio, et al. The metabolic basis of adolescent idiopathic scoliosis: 2011 report of the “metabolic” workgroup of the Fondation Yves Cotrel. 2012. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366135/
12. Richard P. Menger, Piyush Kalakoti, Andrew J. Pugely, et all. Adolescent idiopathic scoliosis: risk factors for complications and the effect of hospital volume on outcomes. 2017. https://sci-hub.se/10.3171/2017.6.FOCUS17300
13. John P. Horne, Robert Flannery, And Saif Usman. Adolescent Idiopathic Scoliosis: Diagnosis and Management. 2014. https://www.aafp.org/afp/2014/0201/p193.html
14. Yu Zheng, Yini Dang, Yan Yang, et al. A Case-Control Study of Body Composition, Prevalence, and CurveSeverity of the Patients With Adolescent Idiopathic Scoliosis in the EastPart of China. 2017. https://sci-hub.se/10.1016/j.jspd.2017.04.002

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